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Published on: October 16, 2013
Plasma concentration and cardiovascular effects of lidocaine during continuous epidural administration in dogs
Iwao Sakonju1, Kenichi Maeda, Koichi Karasawa
1Department of Small Animal Surgery 1, School of Veterinary Medicine, Kitasato University, Towada, Aomori. sakon@vmas.kitasato-u.ac.jp
Abstract:
The cardiovascular effects of continuous epidural administration (CEA) of lidocaine were investigated in anesthetized dogs. Loading epidural injections of 2, 4, or 6 mg/kg of lidocaine were followed by CEA with 1, 2, or 3 mg/kg/hr lidocaine, respectively, for 2 hr under 2.0% isoflurane anesthesia. Heart rate, direct blood pressure, cardiac index, and stroke volume decreased dose-dependently during CEA, whereas systemic vascular resistance did not significantly differ with dose, and no characteristic changes were observed in any groups. Plasma lidocaine concentration reached a steady state during CEA and increased in a dose-dependent manner. Circulatory suppression caused by lidocaine CEA was not attributable to peripheral vasodilation, but rather to the direct cardiac action of systemic lidocaine absorption from the peridural space.
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