[Synthetic studies on kinamycin antibiotics].

Area of Science:

• Natural Product Chemistry
• Organic Synthesis
• Microbiology

Context:

• Kinamycin antibiotics, isolated from Streptomyces murayamaensis, exhibit strong activity against gram-positive bacteria.
• Initial structural determination of kinamycins and prekinamycin as benzo[b]carbazole derivatives was revised.
• Re-examination revealed a benzo[b]fluorene core with a diazoalkane moiety, later revised to benzo[a]fluorene (isoprekinamycin).

Purpose:

• To describe the synthetic approach towards the total synthesis of kinamycin antibiotics.
• To address the structural complexities and revisions of kinamycin and related compounds.
• To contribute to the understanding of benzo[a]fluorene and benzo[b]fluorene natural products.

Summary:

• This review outlines our strategy for the total synthesis of kinamycin antibiotics.
• The synthetic efforts are guided by the ongoing structural determination and revision of these compounds.
• Focus is placed on overcoming challenges in synthesizing the complex benzo[a]fluorene core.

Impact:

• Facilitates further research into the biological activities and mechanisms of kinamycin antibiotics.
• Provides valuable insights into synthetic methodologies for complex polycyclic natural products.
• Contributes to the field of antibiotic discovery and development against resistant bacteria.