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Anti-stress action of several orally-given β-glucans

Vaclav Vetvicka1, Zuzana Vancikova

  • 1University of Louisville, Department of Pathology, KY, USA. Vaclav.vetvicka@louisville.edu

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|November 5, 2010
PubMed
Abstract

Insights

Certain beta-glucans can counteract stress-induced immune suppression. Glucan #300 effectively restored phagocytic activity and cytokine levels (IL-6, IL-12) in mice exposed to cold or restraint stress.

Area of Science:

  • Immunology
  • Stress Physiology
  • Nutritional Science

Background:

  • Beta-glucans are recognized for their immunomodulatory properties.
  • Emerging research indicates glucans can mitigate stress-induced immunosuppression.

Purpose of the Study:

  • To compare the efficacy of four distinct beta-glucan types in counteracting immune suppression induced by cold and restraint stress.
  • To evaluate the impact of beta-glucans on stress markers and immune cell activity.

Main Methods:

  • Mice were exposed to restraint and cold stress protocols.
  • Dietary administration of four different beta-glucans was assessed over 14 days.
  • Phagocytic activity, corticosterone levels, and cytokine (IL-6, IL-12) secretion were measured.

Main Results:

  • Cold stress reduced phagocytic activity by 38%; only glucan #300 normalized this function.
  • Stress significantly increased corticosterone levels, an effect partially blocked by glucan administration.
  • Glucan #300 maintained IL-6 and IL-12 secretion above control levels, unlike other glucans.

Conclusions:

  • While all tested beta-glucans aided immune recovery from stress, their effectiveness varied significantly.
  • Glucan #300 demonstrated superior ability to restore immune function under stress.
  • Results suggest beta-glucans may exert their effects by modulating corticosterone and enhancing cytokine production.

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