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Updated: Jun 7, 2026

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Engineering liposomes and nanoparticles for biological targeting.

Rasmus I Jølck¹, Lise N Feldborg, Simon Andersen

¹Department of Micro- and Nanotechnology, DTU Nanotech, Technical University of Denmark, Frederiksborgvej 399, 4000, Roskilde, Denmark.

Advances in Biochemical Engineering/Biotechnology

|November 5, 2010

Summary

Nanoparticle surface functionalization is key for advanced drug delivery systems. This review critically evaluates strategies for targeting diseased cells and enhancing drug efficacy.

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Nanomaterial engineering for medical applications is rapidly advancing, particularly in drug delivery.
Early nanoparticle designs were simple, but current designs allow for complex surface functionalization and targeted drug release.

Purpose of the Study:

To review and critically evaluate strategies for nanoparticle surface functionalization.
To explore the application of these functionalized nanoparticles in drug delivery systems.

Main Methods:

Overview of various surface functionalization techniques for nanoparticles.
Analysis of how these techniques enable targeting of diseased cells via specific ligands.

Main Results:

Detailed examination of chemical strategies for nanoparticle surface modification.
Discussion of the attachment of diverse targeting ligands (antibodies, peptides, etc.) to nanoparticles.

Conclusions:

Surface functionalization is crucial for developing sophisticated nanoparticle-based drug delivery systems.
Control over nanoparticle surface chemistry is essential for targeted therapeutic applications.