Related Experiment Video
Updated: Jun 7, 2026

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm
Published on: October 3, 2020
Inhibition of return: Twenty years after
Juan Lupianez1, Raymond M Klein, Paolo Bartolomeo
1Departamento de Psicologia Experimental y Fisiologia del Comportamiento, University of Granada, Spain.
Abstract:
When responding to a suddenly appearing stimulus, we are slower and/or less accurate when the stimulus occurs at the same location of a previous event than when it appears in a new location. This phenomenon, often referred to as inhibition of return (IOR), has fostered a huge amount of research in the last 20 years. In this selective review, which introduces a Special Issue of Cognitive Neuropsychology dedicated to IOR, we discuss some of the methods used for eliciting IOR and its boundary conditions. We also address its debated relationships with orienting of attention, succinctly review findings of altered IOR in normal elderly and neuropsychiatric patients, and present results concerning its possible neural bases. We conclude with an outline of the papers collected in this issue, which offer a more in-depth treatment of behavioural, neural, and theoretical issues related to IOR.
Related Concept Videos
Feedback Inhibition
Enzyme Inhibition
Inhibition of CDK Activity
Inhibition of Cdk Activity
Desensitization and Tachyphylaxis
Several...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...

