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Updated: Jun 7, 2026
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Platelet- and megakaryocyte-derived microparticles
Robert Flaumenhaft1, Albert T A Mairuhu, Joseph E Italiano
1Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. rflaumen@bidmc.harvard.edu
Abstract:
Platelet microparticles are the most abundant cell-derived microparticle subtype in the circulation. Yet the mechanism by which platelet microparticles are formed is poorly defined. This review highlights the concept of the generation of microparticles from platelets and their precursor cells, megakaryocytes. Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states.
Insights
Platelet microparticles, abundant in circulation, are generated from platelets and megakaryocytes. This review explores their formation mechanisms and functions in health and disease.
Area of Science:
- Hematology
- Cell Biology
- Biochemistry
Background:
- Platelet microparticles are the most common circulating cell-derived microparticles.
- The precise mechanisms of platelet microparticle formation remain incompletely understood.
Purpose of the Study:
- To review the generation of microparticles from platelets and megakaryocytes.
- To emphasize the mechanisms of microparticle formation.
- To highlight novel functions of microparticles in physiology and disease.
Main Methods:
- Literature review focused on platelet microparticle formation.
- Analysis of mechanisms underlying microparticle generation.
- Synthesis of current knowledge on microparticle functions.
Main Results:
- Platelets and their precursor cells, megakaryocytes, are sources of microparticles.
- Specific cellular processes contribute to microparticle biogenesis.
- Microparticles play diverse roles in normal and pathological conditions.
Conclusions:
- Understanding platelet microparticle formation is crucial.
- Microparticles have significant implications in various physiological and disease states.
- Further research into microparticle functions is warranted.
