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Updated: Jun 7, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Genetic predisposition to papillary thyroid cancer
Dorota Kula1, Michał Kalemba, Beata Jurecka-Lubieniecka
1Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska Curie Memorial Cancer Centre and Institite of Oncology, Gliwice Branch. dkula@io.gliwice.pl
Endokrynologia Polska
|November 5, 2010
Summary
Hereditary thyroid cancer, particularly papillary thyroid cancer (PTC), has unknown susceptibility genes. This review examines linkage analysis and genome-wide association studies (GWAS) for FNMTC insights.
Area of Science:
- Genetics
- Oncology
- Endocrinology
Background:
- Approximately 5% of differentiated thyroid cancers have a hereditary basis.
- Hereditary non-medullary thyroid cancer (FNMTC) can be part of familial cancer syndromes or a primary feature.
- Papillary thyroid cancer (PTC) is the most common type within FNMTC.
Purpose of the Study:
- To review current knowledge on hereditary non-medullary thyroid cancer.
- To discuss identified genetic loci and the application of genome-wide association studies (GWAS).
- To highlight the ongoing search for susceptibility genes in FNMTC.
Main Methods:
- Review of linkage analysis studies using microsatellite markers.
- Analysis of recent genome-wide association studies (GWAS) employing high-resolution SNP arrays.
- Examination of previously reported putative genetic loci (1q21, 6q22, 8p23.1-p22, 8q24).
Main Results:
- Several putative genetic loci for FNMTC have been identified through linkage analysis.
- Validation studies for these loci have thus far been unsuccessful.
- GWAS with SNP arrays represent a more recent approach to identify FNMTC susceptibility genes.
Conclusions:
- The genetic basis of hereditary non-medullary thyroid cancer remains largely unknown.
- Further research, including advanced GWAS, is needed to identify specific susceptibility genes.
- Understanding these genes is crucial for improved genetic counseling and risk assessment in affected families.
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