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Related Experiment Video

Updated: Jun 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Translational research to prevent internalizing problems early in childhood.

Jordana K Bayer1, Ronald M Rapee, Harriet Hiscock

  • 1Centre for Community Child Health, and 3Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.

Depression and Anxiety
|November 5, 2010
PubMed
Summary

Early intervention for internalizing problems in preschoolers is crucial. Translational research is evaluating population-level screening and parenting interventions to prevent these issues effectively.

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Published on: August 25, 2014

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Last Updated: Jun 7, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

  • Child Psychology
  • Developmental Psychiatry
  • Public Health

Background:

  • Internalizing problems affect 1 in 7 school-aged children, with significant long-term impacts.
  • The World Health Organisation (WHO) predicts a substantial global burden of internalizing problems by 2030.
  • Early childhood intervention shows cost-effective benefits for developmental outcomes compared to later interventions.

Purpose of the Study:

  • To discuss the importance of translational research for early prevention of child internalizing problems.
  • To describe an approach to translational effectiveness research for preschooler internalizing issues.
  • To address gaps in early childhood prevention strategies for internalizing disorders.

Main Methods:

  • Review of existing randomized "efficacy" trials of parenting group interventions for inhibited preschoolers.
  • Initiation of translational "effectiveness" research at the population level.
  • Systematic screening of preschoolers for inhibition and subsequent intervention evaluation.

Main Results:

  • Previous efficacy trials demonstrated that parenting interventions reduced internalizing disorders in preschoolers up to 3 years later.
  • Ongoing effectiveness research aims to determine the benefits and harms of population-level screening and intervention.
  • The research addresses critical needs identified by the WHO Prevention of Mental Disorders report.

Conclusions:

  • Early intervention during preschool years is vital for preventing internalizing problems.
  • Translational effectiveness research is essential to implement and scale up evidence-based interventions.
  • Systematic screening and targeted interventions can mitigate the impact of risk factors like temperamental inhibition and overinvolved parenting.