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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Updated: Jun 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Optimizing topical therapies for treating psoriasis: a consensus conference.

Joshua A Zeichner1, Mark G Lebwohl, Alan Menter

  • 1Mount Sinai Medical Center, New York, New York, USA.

Cutis
|November 6, 2010
PubMed
Summary

Psoriasis treatment guidelines were developed in 2010 by dermatologists, emphasizing topical therapies for mild to moderate cases. The guidelines incorporate evidence and clinical experience for lifelong psoriasis management.

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Last Updated: Jun 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Clinical Guidelines
  • Psoriasis Management

Background:

  • Psoriasis is a chronic, lifelong skin condition affecting 80% of patients with mild to moderate disease.
  • Topical therapies are crucial for managing mild to moderate psoriasis.
  • Treatment requires long-term strategies, often evolving from monotherapy to combination approaches.

Framework:

  • Consensus guidelines for psoriasis treatment developed in 2010 by the Psoriasis Process of Care Consensus Panel.
  • Guidelines are evidence-based, integrating extensive clinical experience from dermatologists.
  • Focus on comprehensive care, including adherence, quality of life, and patient-physician relationships.

Implementation:

  • Initial treatment often involves monotherapy.
  • For severe or recalcitrant cases (>10% body surface area [BSA], impaired quality of life [QOL]), combination, sequential, or rotational regimens are utilized.
  • Key treatment modalities include topical steroids, systemic therapies, topical vitamin D, retinoids, phototherapy, and biologics.

Implications:

  • Steroid-sparing topical agents like coal tar, anthralin, calcineurin inhibitors, keratolytics, and emollients offer alternative management options.
  • Optimizing patient adherence and improving quality of life are central therapeutic considerations.
  • Fostering a strong patient-physician relationship is essential for effective long-term psoriasis care.