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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
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Related Experiment Video

Updated: Jun 7, 2026

Sectioning Mammary Gland Whole Mounts for Lesion Identification
09:22

Sectioning Mammary Gland Whole Mounts for Lesion Identification

Published on: July 24, 2017

Lobular carcinoma, not only a classic.

Edi Brogi1, Melissa P Murray, Adriana D Corben

  • 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. brogie@mskcc.org

The Breast Journal
|November 6, 2010
PubMed
Summary

Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia are precursors to invasive breast cancer. Genetic analysis reveals E-cadherin gene inactivation in these lesions, impacting patient management.

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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

Area of Science:

  • Pathology
  • Genetics
  • Oncology

Background:

  • Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia are rare breast lesions often found incidentally.
  • Traditionally considered high-risk, recent evidence suggests they are precursors to invasive carcinoma.

Purpose of the Study:

  • To summarize evolving knowledge of lobular neoplasia.
  • To highlight implications for patient management.

Main Methods:

  • Review of genetic evidence and follow-up data.
  • Analysis of E-cadherin gene status and its role in lesion evaluation.
  • Genetic analysis of rare LCIS variants and pleomorphic invasive lobular carcinoma.

Main Results:

  • Lobular lesions consistently show CDH1/E-cadherin gene deletion or inactivation.
  • E-cadherin loss aids in identifying LCIS variants with distinct morphology and mammographic detection.
  • Rare LCIS variants and pleomorphic invasive lobular carcinoma exhibit more extensive chromosomal alterations.

Conclusions:

  • LCIS and atypical lobular hyperplasia are nonobligate precursors of invasive carcinoma.
  • E-cadherin status is crucial for diagnosing and understanding lobular neoplasia variants.
  • Understanding these lesions impacts diagnostic strategies and patient management.