A new era in the diagnosis and treatment of breast cancer

Related Experiment Video

Updated: Jun 7, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

László Tabár1, Peter B Dean

  • 1Department of Mammography, Falun Central Hospital, Falun, Sweden. laszlo@mammographyed.com

The Breast Journal
|November 6, 2010
PubMed

Insights

Regular mammography screening significantly reduces breast cancer mortality. Early detection through screening leads to smaller tumors and less node involvement, enabling curative local treatment.

Area of Science:

  • Oncology
  • Radiology
  • Public Health

Background:

  • Mammography screening trials have established its efficacy in reducing breast cancer mortality.
  • The effectiveness of screening challenges theories suggesting breast cancer is systemic from onset.

Purpose of the Study:

  • To highlight the impact of mammography screening on breast cancer detection and outcomes.
  • To underscore the shift towards treating localized breast cancer effectively.

Main Methods:

  • Analysis of data from randomized controlled mammography screening trials.
  • Evaluation of service screening programs for breast cancer.

Main Results:

  • Over 50% of invasive cancers detected are small (1-14 mm).
  • Fewer than 20% of screen-detected cancers have positive axillary nodes.
  • Approximately 20% of screen-detected cancers are poorly differentiated.

Conclusions:

  • Mammography screening enables early detection of breast cancer.
  • Early-stage detection facilitates curative local treatment, challenging the necessity of systemic therapy for all screen-detected cancers.
  • Screening has revolutionized breast cancer diagnosis and treatment paradigms.

More Related Videos

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer08:26

Live Imaging of Drug Responses in the Tumor Microenvironment in Mouse Models of Breast Cancer

Published on: March 24, 2013

Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...