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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
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Ghrelin receptor: high constitutive activity and methods for developing inverse agonists.

Sylvia Els1, Annette G Beck-Sickinger, Constance Chollet

  • 1Institute of Biochemistry, Leipzig University, Brüderstrasse, Leipzig, Germany.

Methods in Enzymology
|November 6, 2010
PubMed
Summary

Researchers developed short peptides as inverse agonists to reduce the constitutive activity of the ghrelin receptor, a target for anti-obesity drug development. These peptides show high potency, offering a new strategy for appetite regulation and energy homeostasis.

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