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G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain
F Okada1, T J Crow, G W Roberts
1Health Administration Center, Hokkaido University, Sapporo, Japan.
Journal of Neural Transmission. General Section
|January 1, 1990
Abstract:
We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.