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Mouse In Vivo Placental Targeted CRISPR Manipulation

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Ethical issues in perinatal genetics.

Frank A Chervenak¹, Laurence B McCullough

¹Department of Obstetrics and Gynecology, New York Weill Cornell Medical Center, New York, New York, USA. fac2001@med.cornell.edu

Seminars in Fetal & Neonatal Medicine

|November 6, 2010

Summary

This summary is machine-generated.

This article introduces the ethical principles of beneficence and respect for autonomy in perinatal genetics. It proposes a framework viewing the fetus as a patient for risk assessment and managing genetic anomalies.

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Area of Science:

Perinatal genetics
Bioethics
Medical ethics

Background:

Ethics is crucial in perinatal genetics.
Existing frameworks may not fully address the fetus's status.
Perinatologists require guidance on ethical decision-making.

Purpose of the Study:

Introduce perinatologists to key ethical principles.
Articulate the ethical concept of the fetus as a patient.
Provide an ethical framework for risk assessment and management.

Main Methods:

Review of ethical principles: beneficence and respect for autonomy.
Application of principles to define the fetus as a patient.
Development of an ethical framework for clinical practice.

Main Results:

The fetus can be ethically conceptualized as a patient.
An ethical framework integrating beneficence and autonomy is proposed.
This framework aids in classifying patients for targeted genetic counseling and management.

Conclusions:

Ethical principles provide a robust foundation for perinatal genetics.
Viewing the fetus as a patient enhances care for genetic anomalies.
The proposed framework supports responsible management of high-risk pregnancies.