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Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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P2CS: a database of prokaryotic two-component systems.

Mohamed Barakat1, Philippe Ortet, David E Whitworth

  • 1CEA, DSV, IBEB, SBVME, LEMiRE, F-13108 Saint-Paul-lez-Durance, France. mohamed.barakat@cea.fr

Nucleic Acids Research
|November 6, 2010
PubMed
Summary

The P2CS database offers comprehensive annotation and classification of prokaryotic two-component systems (TCSs) from genomes and metagenomes. It aids researchers in understanding cellular signaling pathways and discovering novel TCS genes.

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Published on: November 12, 2012

Area of Science:

  • Microbiology
  • Bioinformatics
  • Systems Biology

Background:

  • Two-component systems (TCSs) are crucial signaling proteins in prokaryotes, regulating diverse physiological processes.
  • Accurate annotation and classification of TCS proteins are essential for understanding prokaryotic cell biology.

Purpose of the Study:

  • To present P2CS, a specialized database for annotating and classifying prokaryotic TCS proteins.
  • To provide comprehensive data and tools for exploring TCS complements from sequenced prokaryotic genomes and metagenomes.

Main Methods:

  • Curated annotation and classification of TCS proteins from complete prokaryotic genomes and metagenomes.
  • Integration of sequence-feature information, external prediction server queries, and ORFeome analysis.
  • Development of browsing, searching, and data download functionalities.

Main Results:

  • P2CS provides detailed annotations for TCS proteins, including replicon context and predicted properties.
  • The database facilitates identification of homologous proteins, interaction networks, and sub-cellular localization.
  • Novel TCS genes missed during genome annotation were identified through ORFeome analysis.

Conclusions:

  • P2CS serves as a valuable resource for researchers studying prokaryotic signal transduction.
  • The database enhances the discovery and characterization of two-component systems in prokaryotes.
  • Recent innovations improve the visualization, classification, and accessibility of TCS data.