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Related Experiment Video

Updated: Jun 7, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Novel and Innovative Hybrid Technique for Type A Aortic Dissection

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Type A dissection in young patients.

Lars Niclauss1, Dominique Delay, Ludwig Karl von Segesser

  • 1Department of Cardiovascular Surgery, University Hospital CHUV, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Lars.Niclauss@chuv.ch

Interactive Cardiovascular and Thoracic Surgery
|November 6, 2010
PubMed
Summary

Type A aortic dissection in patients under 40 is rare but treatable. Surgical repair offers excellent long-term survival, though aortic root dilatation is a common re-operation cause.

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Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Vascular Surgery

Background:

  • Type A aortic dissection is a life-threatening condition with unpredictable outcomes.
  • Onset typically occurs in the sixth decade, but is earlier with connective tissue abnormalities.
  • Dissection in young patients (<40 years) is rare, necessitating focused study.

Purpose of the Study:

  • To analyze the pathology, risk factors, and postoperative progression of Type A aortic dissection in young patients.
  • To identify specific etiologies and outcomes in this understudied demographic.

Main Methods:

  • Retrospective analysis of 27 patients (<40 years) operated for Type A aortic dissection (July 1968 - February 2009).
  • Cross-sectional follow-up via phone interview and imaging (echocardiography/CT-scan) in December 2009.

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Last Updated: Jun 7, 2026

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Main Results:

  • Connective tissue disease (46%) and bicuspid aortic valve (BAV) (22%) were primary causes.
  • Early in-hospital mortality was 11%; 26% experienced neurological complications.
  • Mean follow-up of 117 months showed 8% late mortality; aortic root dilatation occurred in ~40% post-simple replacement.

Conclusions:

  • Connective tissue diseases, BAV, hypertension, vascular issues, and cocaine abuse are key etiologies in young patients.
  • Early mortality linked to coronary dissection and neurological disorders.
  • Surgical repair provides lifesaving treatment with excellent long-term survival for young patients with Type A dissection.