Related Experiment Video
Updated: Jun 7, 2026
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
"Skulls and bones" new member: Th17.
1Moffitt Cancer Center & Research Institute.
Blood
|November 6, 2010
Summary
T-helper 17 (Th17) cells, a T cell subpopulation, are identified as key regulators of myeloma-associated bone disease. This finding challenges the established view of osteoclast-mediated bone destruction in multiple myeloma.
Area of Science:
- Immunology
- Oncology
- Bone Biology
Background:
- Multiple myeloma is associated with osteolytic bone lesions.
- Osteoclast activity is considered the primary driver of myeloma-related bone destruction.
- The tumor microenvironment plays a crucial role in disease progression.
Discussion:
- This study investigates the role of T-helper 17 (Th17) cells in myeloma-induced bone disease.
- It challenges the paradigm that osteoclasts are the sole mediators of bone lesions in multiple myeloma.
- Th17 cells are proposed as a significant regulator within the myeloma microenvironment impacting bone.
Key Insights:
- A subpopulation of T cells, Th17 cells, are identified as key regulators of bone disease in multiple myeloma.
- This research suggests a more complex interplay between immune cells and bone pathology in myeloma.
- The findings implicate Th17 cells in the pathogenesis of osteolytic lesions adjacent to myeloma cells.
Outlook:
- Further research is needed to elucidate the precise mechanisms by which Th17 cells influence bone metabolism in myeloma.
- Targeting Th17 cells could represent a novel therapeutic strategy for managing bone disease in multiple myeloma patients.
- Understanding the role of Th17 cells may lead to improved treatment outcomes for multiple myeloma bone complications.
Related Concept Videos
01:30Bone Cells and Tissue
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:09Spongy Bone
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:28Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...