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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Left ventricular systolic synchrony in dilated cardiomyopathy patients with normal QRS wave

Na Yi1, Saidan Zhang

  • 1Department of Cardiovasology, Xiangya Hospital, Central South University, Changsha 410008, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|November 6, 2010
PubMed

Insights

Left ventricular systolic dyssynchrony (LV-SD) is present in dilated cardiomyopathy patients with normal QRS width. This dyssynchrony worsens systolic function and is linked to remodeling and mitral regurgitation.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Dilated cardiomyopathy (DCM) with chronic heart failure (CHF) often involves complex cardiac dysfunction.
  • Assessing left ventricular systolic dyssynchrony (LV-SD) is crucial for understanding disease progression.

Purpose of the Study:

  • To evaluate LV-SD distribution in DCM patients with CHF and normal QRS width using pulsed-wave Doppler tissue imaging (PW-DTI).
  • To investigate the relationship between LV-SD and left ventricular systolic function, remodeling, and functional mitral regurgitation (FMR).

Main Methods:

  • Pulsed-wave Doppler tissue imaging (PW-DTI) was used to measure the time to peak systolic velocity (Ts) in 12 left ventricular segments.
  • Calculated standard deviation of Ts (Ts-SD) and maximum Ts difference (Ts-maxD) to quantify LV-SD.

Main Results:

  • DCM patients with CHF exhibited significantly higher Ts-SD and Ts-maxD compared to healthy controls.
  • LV-SD was identified in 29.8% of DCM patients with normal QRS width, with the inferior wall most affected.
  • LV-SD correlated negatively with left ventricular ejection fraction (LVEF) and positively with left ventricular volumes, NYHA class, and FMR.

Conclusions:

  • LV-SD is a significant finding in DCM patients even with normal QRS width.
  • LV-SD exacerbates left ventricular systolic dysfunction and is associated with cardiac remodeling.
  • LV-SD may play a role in the development of FMR in DCM.
Abstract

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