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Related Experiment Video

Updated: Jun 7, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Chorioamnionitis and mid-trimester pregnancy loss.

Austin Ugwumadu¹

¹Department of Obstetrics and Gynaecology, St George's Hospital, London, UK. augwumad @ sgul.ac.uk

Gynecologic and Obstetric Investigation

|November 6, 2010

Summary

Mid-trimester pregnancy loss and preterm birth share common causes and risks, often stemming from ascending infections. Understanding this link is key to preventing both conditions.

Area of Science:

Obstetrics and Gynecology
Infectious Diseases

Background:

Mid-trimester pregnancy loss (14-23 weeks) and early preterm birth (24-28 weeks) share pathogenic and socio-biologic risk factors.
Ascending infection from the lower genital tract is a primary cause for both conditions.
Prior history of either condition increases the risk for the other, suggesting a spectrum of disease.

Purpose of the Study:

To investigate the role of chorioamnionitis in mid-trimester pregnancy loss.
To evaluate current interventions for reducing the recurrence of mid-trimester pregnancy loss.

Main Methods:

Review of literature on the pathogenesis of mid-trimester pregnancy loss.
Analysis of risk factors and clinical manifestations.
Assessment of intervention efficacy for recurrence reduction.

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Main Results:

Mid-trimester loss and preterm birth are manifestations of the same disease process.
Ascending infections are the predominant cause.
Chorioamnionitis plays a significant role in mid-trimester pregnancy loss pathogenesis.

Conclusions:

Mid-trimester miscarriage is the lower spectrum of preterm birth.
Chorioamnionitis is a critical factor in mid-trimester pregnancy loss.
Further research on interventions is needed to reduce recurrence.