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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Updated: Jun 7, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

MicroRNAs in vascular disease.

Shanshan Qin1, Chunxiang Zhang

  • 1RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA.

Journal of Cardiovascular Pharmacology
|November 6, 2010
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are small RNAs regulating gene expression and are crucial in vascular health. Dysregulated miRNA expression is linked to vascular diseases, suggesting therapeutic potential.

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MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
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Last Updated: Jun 7, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

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Published on: June 15, 2018

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression.
  • They influence multiple target genes, acting as key regulators in cellular processes.
  • miRNAs are highly expressed in vasculature and implicated in various physiological and pathological conditions.

Purpose of the Study:

  • To review the current research on the role of miRNAs in vascular diseases.
  • To highlight the involvement of miRNAs in vascular cell functions and disease pathogenesis.
  • To explore the potential of miRNAs as therapeutic targets for vascular conditions.

Main Methods:

  • Literature review of recent studies on miRNAs and vascular diseases.
  • Analysis of miRNA involvement in vascular cell functions (differentiation, migration, apoptosis).
  • Examination of miRNA dysregulation in conditions like atherosclerosis, hypertension, and diabetic vascular complications.

Main Results:

  • miRNAs are critical modulators of vascular cell functions.
  • Dysregulated miRNA expression is observed in diseased blood vessels.
  • miRNAs play significant roles in vascular dysfunction, angiogenesis, and lesion formation.

Conclusions:

  • miRNAs are pivotal regulators in vascular health and disease.
  • Targeting miRNAs offers a promising therapeutic strategy for a range of vascular diseases.
  • Further research is warranted to fully elucidate miRNA functions and therapeutic applications in vascular medicine.