Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Smooth Muscle Contraction01:25

Smooth Muscle Contraction

Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of Benzophenanthridine Alkaloids from <i>Zanthoxylum nitidum</i> That Target the MDM2-p53 Axis in NSCLC.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

AI-driven Medical Care: Evaluation of Large Language Models in Generating Personalized Stroke Education Materials.

Healthcare informatics research·2026
Same author

Fluid shear regulation of local Ca<sup>2+</sup> transients in right and left rat atrial myocytes under normal and increased beating rate.

American journal of physiology. Cell physiology·2026
Same author

Clinical Features of Surgically Managed Adnexal Masses in Children and Adolescents at a Tertiary Referral Center.

Children (Basel, Switzerland)·2026
Same author

Distinct immunophenotypic and clinical features of TP53-mutated acute myeloid leukemia: high CD34/CD41 expression and lower leukocyte counts.

Annals of hematology·2026
Same author

Identification of an Elusive <i>CBFA2T3::GLIS2</i> Fusion Variant in Acute Megakaryoblastic Leukemia by Whole Genome Sequencing.

EJHaem·2026

Related Experiment Video

Updated: Jun 7, 2026

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
09:50

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

Chrysosplenol C increases contraction in rat ventricular myocytes.

Min-Jeong Son1, Hyun Kyung Kim, Do Thi Thu Huong

  • 1College of Pharmacy, IDRD, Chungnam National University, 220 Gungdong, Yuseong-Gu, Daejeon 305-764, South Korea.

Journal of Cardiovascular Pharmacology
|November 6, 2010
PubMed
Summary
This summary is machine-generated.

Chrysosplenol C, a natural flavone, enhances cardiac myocyte contractility. This compound acts as a positive inotropic agent, increasing cell shortening in a dose-dependent manner without affecting relaxation velocity.

More Related Videos

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
07:56

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

Published on: June 8, 2022

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes
07:32

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Published on: May 25, 2022

Related Experiment Videos

Last Updated: Jun 7, 2026

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
09:50

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses
07:56

Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

Published on: June 8, 2022

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes
07:32

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Published on: May 25, 2022

Area of Science:

  • Cardiology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Chrysosplenol C is a flavone found in medicinal plants like Miliusa balansae.
  • Known for antiviral and cytotoxic activities, its effects on cardiac function were unexplored.

Purpose of the Study:

  • To investigate the impact of Chrysosplenol C on the contractility of isolated adult rat ventricular myocytes.
  • To characterize the mechanism of action of Chrysosplenol C on cardiac muscle.

Main Methods:

  • Chrysosplenol C was isolated from M. balansae.
  • Single myocytes were field-stimulated, and cell shortening was measured using video edge detection.
  • Dose-response, reversibility, and effects of propranolol and H-89 were assessed.

Main Results:

  • Chrysosplenol C demonstrated a dose-dependent positive inotropic effect, increasing cell shortening up to 185% of control.
  • The effect was maximal at ≥80 μM and reversible.
  • Time to peak contraction and relengthening increased; relaxation velocity was unchanged.

Conclusions:

  • Chrysosplenol C is a novel positive inotropic agent in cardiac myocytes.
  • Its mechanism is independent of beta-adrenergic receptor stimulation and protein kinase A.
  • Further research into Chrysosplenol C for cardiac applications is warranted.