Related Experiment Videos
c-fos and c-myc expression in human endothelial cells as a function of different culture conditions
M G Lampugnani1, N Polentarutti, M Pedenovi
1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Experimental Cell Research
|February 1, 1990
Abstract:
Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.