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Updated: Jun 7, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
IL-12 and related cytokines: function and regulatory implications in Candida albicans infection
Robert B Ashman1, Dipti Vijayan, Christine A Wells
1The School of Dentistry, University of Queensland School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia. r.ashman@uq.edu.au
Abstract:
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.
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