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Related Concept Videos

Vision01:24

Vision

Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Mouse model resources for vision research.

Jungyeon Won1, Lan Ying Shi, Wanda Hicks

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Journal of Ophthalmology
|November 6, 2010
PubMed
Summary
This summary is machine-generated.

Mouse models are crucial for understanding human diseases and testing treatments. Researchers developed novel mutant mouse lines for vision research, including three new alleles for Crx, Rp1, and Rpe65 genes.

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Area of Science:

  • Ophthalmology and Vision Science
  • Genetics and Genomics
  • Translational Medicine

Background:

  • Mouse models are essential for studying human diseases due to genetic and physiological similarities.
  • Mutant mice facilitate the analysis of developmental defects and the testing of therapeutic strategies for human disorders.
  • Reproducible experimental systems are vital for understanding normal development and function.

Purpose of the Study:

  • To describe the development and utility of mutant mouse models for vision research.
  • To highlight the contributions of the Eye Mutant Resource and Translational Vision Research Models (TVRM) programs.
  • To report novel alleles in key vision genes as examples of the TVRM program's success.

Main Methods:

  • Development of over 100 mutant lines via the Eye Mutant Resource and 60 lines via the TVRM program.
  • Characterization of ocular disease phenotypes, including cataracts, retinal dysplasia/degeneration, and abnormal vasculature.
  • Genetic mapping and sequencing to identify mutations in disease genes.

Main Results:

  • A diverse collection of mutant mouse lines with various ocular disease phenotypes has been generated.
  • Three novel mutant alleles (Crx(tvrm65), Rp1(tvrm64), and Rpe65(tvrm148)) were successfully created and characterized.
  • These novel alleles closely mimic previously reported knockout models, validating their utility.

Conclusions:

  • The Eye Mutant Resource and TVRM programs provide valuable genetic tools for vision research.
  • Mutant mouse models are instrumental in dissecting the genetic basis of ocular diseases.
  • The reported novel alleles offer new resources for studying Crx, Rp1, and Rpe65 gene functions in vision.