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Diabetes and depression.

Antonio Campayo¹, Carlos H Gómez-Biel, Antonio Lobo

¹Hospital Clínico Universitario, Zaragoza, Spain. acampayo.iacs@aragon.es

Current Psychiatry Reports

|November 6, 2010

Summary

The link between diabetes mellitus and depression is complex, with each condition increasing the risk of the other. Treating depression may be beneficial, but more research is needed on treatment efficacy and safety in diabetic patients.

Area of Science:

Endocrinology
Psychiatry
Public Health

Background:

Diabetes mellitus and depression are increasingly prevalent globally.
Comorbidity of these conditions is associated with negative health outcomes.
The bidirectional relationship between diabetes and depression requires further investigation.

Purpose of the Study:

To review the multifaceted association between diabetes mellitus and depression.
To examine the impact of each condition on the other.
To discuss implications for clinical practice and future research.

Main Methods:

Literature review of community studies and psychosomatic hypotheses.
Analysis of prevalent and incident depression in diabetic patients.

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Assessment of diabetes risk in depressed individuals, including nonsevere, persistent, untreated depression.

Main Results:

Diabetic patients show increased risks of prevalent and incident depression.
Depressed patients exhibit an increased risk of developing diabetes.
Nonsevere, persistent, untreated depression is linked to a higher risk of diabetes.

Conclusions:

The association between diabetes and depression is complex and bidirectional.
Treating clinically relevant depression in the community is logical given negative implications.
Further studies are essential to confirm the efficacy of depression treatment and safety of antidepressants in comorbid cases.