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Evaluation of nailfold capillaries in familial Mediterranean fever patients

Sevil Aytekin1, Fatma Aydin, Tekin Akpolat

  • 1Department of Dermatology, Ondokuz Mayis University School of Medicine, 55139 Kurupelit, Samsun, Turkey.

Clinical Rheumatology
|November 6, 2010
PubMed

Insights

Familial Mediterranean fever (FMF) patients may show nailfold capillary abnormalities. These nonspecific findings, including capillary enlargement and microhemorrhages, warrant further investigation to understand their significance in FMF.

Area of Science:

  • Rheumatology
  • Genetics
  • Dermatology

Background:

  • Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease.
  • FMF presents with recurrent febrile attacks and symptoms like abdominal pain, joint pain, and skin lesions.
  • Associated vasculitic conditions include polyarteritis nodosa and Henoch-Schönlein purpura.

Purpose of the Study:

  • To investigate microvascular abnormalities in FMF patients.
  • To utilize nailfold capillaroscopy with dermoscopy for detailed microvascular assessment.

Main Methods:

  • Nailfold capillaroscopy was performed on thirty-one FMF patients.
  • Assessment focused on capillary enlargement, tortuosity, avascular areas, and microhemorrhages.

Main Results:

  • Capillary enlargement was observed in five FMF patients.
  • Microhemorrhages were noted in one FMF patient.
  • The observed nailfold capillary abnormalities were nonspecific.

Conclusions:

  • Nonspecific nailfold capillary abnormalities can be present in patients with Familial Mediterranean fever.
  • Further research is required to elucidate the clinical significance of these microvascular findings in FMF.

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