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Updated: Jun 7, 2026

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

Microfluidic blood filtration device.

George Maltezos¹, John Lee, Aditya Rajagopal

¹Department of Electrical Engineering, California Institute of Technology, MC 136-93, Pasadena, CA 91125, USA.

Biomedical Microdevices

|November 6, 2010

Summary

This summary is machine-generated.

A new microfluidic device efficiently separates plasma from whole blood at low pressure. This innovation enables low-cost, point-of-care diagnostics, moving towards accessible finger-prick blood tests.

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Published on: February 22, 2016

Area of Science:

Biomedical Engineering
Medical Diagnostics
Microfluidics

Background:

Increasing healthcare costs and personnel demands necessitate rapid, decentralized diagnostic solutions.
Point-of-care (POC) diagnostics require efficient on-site sample preparation from small sample volumes.
Existing methods often lack the low-cost, bedside-operable devices needed for widespread POC adoption.

Purpose of the Study:

To introduce a novel, low-cost microfluidic device for whole blood plasma separation.
To demonstrate the device's compatibility with existing microfluidic diagnostic platforms.
To advance the integration of sample preparation within microfluidic diagnostic chips for POC applications.

Main Methods:

Development of an inexpensive, easy-to-fabricate microfluidic device.
Operation of the device using a low pressure requirement (3.5 kPa).
Integration of a filter encapsulation technique within an elastomeric microfluidic chip.

Main Results:

The microfluidic device successfully produces plasma from whole blood.
The device is reliable, inexpensive, and operates at low pressure.
The device's output is directly compatible with microfluidic diagnostic chip input ports.

Conclusions:

The developed microfluidic device is a viable solution for point-of-care plasma separation.
This technology facilitates the integration of sample preparation into microfluidic diagnostic systems.
The approach paves the way for advanced, accessible finger-prick blood testing at the point of care.