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Updated: Jun 7, 2026
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Outcome of augmentation cystoplasty and bladder substitution in a pediatric age group
F Obermayr1, P Szavay, J Schaefer
1University of Tübingen, Department of Pediatric Surgery, Tübingen, Germany. florian.obermayr@med.unituebingen.de
Insights
Pediatric bladder reconstruction using augmentation cystoplasty or bladder substitution improves continence and preserves kidney function. However, these procedures are associated with significant complications, requiring careful patient selection and monitoring.
Area of Science:
- Pediatric Urology
- Reconstructive Surgery
- Urodynamics
Background:
- Intractable lower urinary tract disease in children necessitates advanced surgical interventions.
- Augmentation cystoplasty and bladder substitution are established reconstructive techniques.
Purpose of the Study:
- To evaluate the outcomes of augmentation cystoplasty and bladder substitution in pediatric patients.
- To assess functional results and complication rates of these reconstructive bladder surgeries.
Main Methods:
- Retrospective review of patient records for children undergoing reconstructive bladder surgery (October 1999 - November 2007).
- Standardized postoperative outcome evaluation through patient interviews.
- Analysis of urodynamic parameters, renal function, continence, and complication rates.
Main Results:
- Augmentation cystoplasty (19 patients) and bladder substitution (6 patients) were performed. Continent catheterizable vesicostomy was done in 21 patients.
- Significant improvements in bladder volume (median 400 ml) and compliance (median 13.5 ml/cmH2O) were observed.
- 90% achieved social continence; renal function remained stable in 95%. Major complications included calculi (39%), vesicostomy issues (28%), and obstruction (9%).
Conclusions:
- Augmentation cystoplasty and bladder substitution effectively preserve renal function and achieve urinary continence in pediatric patients with complex bladder conditions.
- Despite benefits, these procedures carry a substantial risk of complications, highlighting the need for vigilant management.
Objective:
Aim of the study was to evaluate the outcome of augmentation cystoplasty and bladder substitution in a pediatric age group.
Methods:
Patient records of all children who underwent reconstructive bladder surgery between October 1999 and November 2007 were reviewed. Additionally, standardized interviews were performed to evaluate the postoperative outcome.
Results:
Augmentation cystoplasty and bladder substitution were performed in 19 and 6 patients, respectively. 21 patients underwent continent catheterizable vesicostomy. Postoperative urodynamics revealed a significant increase in bladder volume (median 400 ml) as well as a significant improvement in bladder compliance (median 13.5 ml/cmH2O). 90% of the patients were reported to be socially continent. Renal function remained stable in 95% and decreased in 5% of the children. Major complications were lower urinary tract calculi (39%), stricture or insufficiency of the continent vesicostomy (28%), and intestinal obstruction (9%). No malignancies associated to bladder augmentation or substitution were detected yet.
Conclusion:
Augmentation cystoplasty and bladder substitution preserve renal function and provide urinary continence in most children with intractable lower urinary tract disease. However, the procedures remain associated with numerous complications.
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