Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophagus01:24

Esophagus

The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Incidental discovery of an immunoglobulin deficiency].

Revue medicale suisse·2015
Same author

[Cardiac involvement in connective tissue disease: the example of systemic lupus erythematosus].

Revue medicale suisse·2010
Same author

[Rare food allergies].

Revue medicale suisse·2008
Same author

[The multiple etiologies of angioedema].

Revue medicale suisse·2008
Same author

[When should consider antiphospholipid syndrome?].

Revue medicale suisse·2008
Same author

[Modern nutrition and development of new allergies].

Revue medicale suisse·2007
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

Revue medicale suisse·2026
Same journal

[Erythema multiforme : target deciphering].

Revue medicale suisse·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic esophagitis].

M Odman1, P A Bart

  • 1Service d'ORL et de chirurgie cervico-faciale, CHUV, 1011 Lausanne. micaela.oedman@chuv.ch

Revue Medicale Suisse
|November 9, 2010
PubMed
Summary
This summary is machine-generated.

Eosinophilic esophagitis, a growing condition, requires physician consideration for dysphagia and GERD symptoms resistant to treatment. Diagnosis involves clinical signs, endoscopy, and biopsies showing over 15 eosinophils, with allergic origins and topical steroid treatment recommended.

More Related Videos

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Using the Endoscope for Endobronchial Ultrasound in the Esophagus
04:35

Using the Endoscope for Endobronchial Ultrasound in the Esophagus

Published on: November 21, 2023

Related Experiment Videos

Last Updated: Jun 7, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Using the Endoscope for Endobronchial Ultrasound in the Esophagus
04:35

Using the Endoscope for Endobronchial Ultrasound in the Esophagus

Published on: November 21, 2023

Area of Science:

  • Gastroenterology and Immunology
  • Allergy and Clinical Immunology

Context:

  • Eosinophilic esophagitis (EoE) is an increasingly recognized esophageal inflammatory condition.
  • It presents as a differential diagnosis in adults and children with dysphagia, food impaction, or proton-pump inhibitor-resistant gastroesophageal reflux disease (GERD) symptoms.

Purpose:

  • To outline the diagnostic criteria and recommended management strategies for eosinophilic esophagitis.
  • To emphasize the allergic etiology and the importance of immuno-allergic testing.

Summary:

  • Diagnosis combines clinical presentation, endoscopic findings, and esophageal mucosal biopsies demonstrating over 15 eosinophils per high-power field.
  • Management involves proton-pump inhibitors to reduce inflammation, topical steroids, and systemic treatment for severe cases.
  • Esophageal dilation may be used for strictures but carries a high recurrence risk.

Impact:

  • Highlights the need for increased physician awareness of EoE.
  • Provides a framework for accurate diagnosis and evidence-based treatment, potentially improving patient outcomes.
  • Underscores the allergic basis, guiding further research into targeted therapies.