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Published on: September 20, 2019
A randomized, open-label, positively-controlled field trial of a hydrolyzed protein diet in dogs with chronic small
P J J Mandigers1, V Biourge, T S G A M van den Ingh
1Department of Clinical Sciences of Companion Animals, Utrecht University, The Netherlands.
Background:
Hydrolyzed protein diets are commonly used to manage canine chronic enteropathies (CE), but their efficacy has not yet been critically evaluated.
Hypothesis:
A hydrolyzed protein diet is superior to that of a highly digestible (control) diet in the management of CE in dogs.
Animals:
Twenty-six dogs (18 test diet, 8 control diet) referred for investigation and management of naturally occurring chronic small intestinal disease.
Methods:
Randomized, open-label, positively controlled trial. After a full diagnostic investigation, which included endoscopy, dogs were assigned either to the test diet or control diet on a 2:1 basis (test:control). Cases were re-evaluated 3 times (at approximately 3, 6-12 months, and 3 years). Outcome measures included response of clinical signs (complete, partial, none), change in severity of signs (based upon clinical disease activity index; canine inflammatory bowel disease activity index [CIBDAI]), change in body weight, and need for other therapy.
Results:
There were no significant differences in baseline characteristics (eg, signalment, body weight, and duration of clinical signs), and histopathologic severity between test and control diet groups. However, despite randomization, CIBDAI was significantly higher in the test diet group (P=.013). Most dogs had responded by first evaluation, with no difference between groups (P=.87). However, significantly more dogs on the test diet remained asymptomatic at both the second (P=.0012) and third (P<.001) re-evaluation, and the decrease in CIBDAI was significantly greater (P=.010).
Conclusions And Clinical Importance:
A hydrolyzed protein diet can be highly effective for long-term management of canine chronic small bowel enteropathy.
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