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Related Experiment Video

Updated: Jun 7, 2026

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Chronic pruritus: a paraneoplastic sign.

Gil Yosipovitch¹

¹Department of Dermatology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA. gyosipov@wfubmc.edu

Dermatologic Therapy

|November 9, 2010

Summary

Chronic itch may signal underlying cancer, particularly lymphoma. Early detection and specific treatments targeting itch pathways are crucial for managing this symptom in malignancy.

Area of Science:

Oncology
Dermatology
Neurology

Background:

Chronic itch can be an early indicator of malignancy, often preceding other symptoms.
Lymphoma-associated pruritus is a common example of paraneoplastic itch.
Paraneoplastic pruritus is linked to solid tumors and various skin conditions.

Purpose of the Study:

To review the association between itch and malignancy.
To present new findings on the pathophysiology of malignancy-associated itch.
To discuss treatment strategies for itch in cancer patients.

Main Methods:

Literature review focusing on paraneoplastic pruritus.
Analysis of pathophysiological mechanisms.
Evaluation of current and novel therapeutic approaches.

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Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

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Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

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Published on: June 26, 2016

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

Main Results:

Itch is a significant symptom in various malignancies, including lymphoma and solid tumors.
Understanding pathophysiological mechanisms is key to developing targeted therapies.
Combinative therapies show promise in managing malignancy-associated itch.

Conclusions:

A high index of suspicion for malignancy is warranted in cases of unexplained chronic itch.
Targeted therapies, including SSRIs, SNRIs, kappa opioids, and neuroleptics, are vital for symptom management.
Further research into itch mechanisms and treatment is essential.