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Related Experiment Video

Updated: Jun 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

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Published on: May 30, 2025

Satisfaction profiles in men using intracavernosal injection therapy.

Wayland Hsiao1, Nelson Bennett, Patricia Guhring

  • 1Weill Cornell Medical College, Department of Urology, Center for Male Reproductive Medicine, New York, NY 10021, USA.

The Journal of Sexual Medicine
|November 9, 2010
PubMed
Summary

Intracavernosal injection therapy (ICI) provides high satisfaction for erectile dysfunction (ED) patients who continue treatment. Older age, younger partner age, and achieving fully rigid erections predict greater satisfaction.

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Published on: December 28, 2021

Area of Science:

  • Urology
  • Andrology
  • Sexual Medicine

Background:

  • Intracavernosal injection therapy (ICI) is a key second-line treatment for erectile dysfunction (ED).
  • Patient satisfaction with ICI compared to oral phosphodiesterase type 5 inhibitors (PDE5i) remains a subject of debate.
  • This study evaluates satisfaction within a contemporary patient group using ICI in the current therapeutic landscape.

Purpose of the Study:

  • To assess patient satisfaction with Intracavernosal Injection Therapy (ICI) in an era dominated by oral phosphodiesterase type 5 inhibitors (PDE5i).
  • To identify predictors of satisfaction among patients undergoing ICI for erectile dysfunction (ED).

Main Methods:

  • A cohort of 122 patients on ICI for at least six months was studied.
  • The International Index of Erectile Function (IIEF) and Erection Hardness Scale (EHS) were administered at baseline and follow-up visits.
  • Multivariate logistic regression analysis was used to determine predictors of satisfaction.

Main Results:

  • Sixty-five percent of patients continued ICI therapy at a mean follow-up of 25 months.
  • Significant improvements were observed in intercourse satisfaction (P<0.01) and overall satisfaction domains (P<0.05) of the IIEF.
  • Predictors of satisfaction included older patient age (OR=2.1), younger partner age (OR=2.5), improved erectile function (IIEF domain score increase, OR=3.1), and achieving EHS 4 (fully rigid erections, OR=6.8).

Conclusions:

  • Despite significant dropout rates, ICI demonstrates high patient satisfaction among those who continue therapy.
  • Older patient age, younger partner age, and achieving fully rigid erections are associated with increased satisfaction.
  • ICI remains an effective and robust second-line treatment option for erectile dysfunction (ED), even with the availability of PDE5 inhibitors.