Related Experiment Video

Updated: Jun 7, 2026

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre

A B Chang1, C F Robertson, P P van Asperen

  • 1Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia. annechang@ausdoctors.net

Trials
|November 9, 2010
PubMed

Insights

This study evaluates an evidence-based pathway for managing chronic cough in children, aiming to improve clinical outcomes and quality of life. The pathway proved feasible and reliable in a multicentre randomized controlled trial.

Area of Science:

  • Pediatric respiratory medicine
  • Clinical trial methodology
  • Evidence-based healthcare

Background:

  • Chronic cough in children presents significant human and economic costs.
  • Current management of pediatric chronic cough requires improvement.
  • The symptom can indicate serious underlying conditions or be benign.

Purpose of the Study:

  • To test the feasibility and reliability of an evidence-based management pathway for pediatric chronic cough.
  • To assess the impact of this pathway on clinical outcomes, including quality of life.
  • To provide evidence supporting optimal management strategies for chronic cough in children.

Main Methods:

  • A multicentre randomized controlled trial involving 250 children with new-onset chronic cough.
  • Comparison between a standardized clinical management pathway and usual care.
  • Data collection included cough diaries, quality of life measures (QOL), and follow-up for 6 months post-diagnosis.

Main Results:

  • Primary outcomes focus on group differences in quality of life (QOL) and the proportion of children who are cough-free at 6 weeks.
  • The study assesses the feasibility and reliability of implementing the evidence-based pathway.
  • Results will inform the effectiveness of the standardized pathway in improving pediatric chronic cough outcomes.

Conclusions:

  • The developed clinical management pathway integrates Cochrane Reviews and extensive clinical experience.
  • This study aims to provide crucial evidence on the best practices for managing chronic cough in pediatric populations.
  • Findings will contribute to optimizing the care of children experiencing persistent cough.
Abstract

Related Concept Videos

Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.