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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Both high and low body mass indexes are prognostic risks in Japanese patients with chronic heart failure:

Kotaro Nochioka1, Nobuyuki Shiba, Haruka Kohno

  • 1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Journal of Cardiac Failure
|November 9, 2010
PubMed

Insights

Both low and high body mass index (BMI) are linked to worse outcomes in Japanese heart failure (HF) patients. Maintaining a healthy BMI is crucial for improving prognosis in this population.

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Research

Background:

  • The prognostic significance of body mass index (BMI) in Japanese patients diagnosed with chronic heart failure (HF) requires further elucidation.
  • Existing research on BMI and HF prognosis has yielded inconsistent findings, particularly within diverse ethnic populations.

Purpose of the Study:

  • To investigate the association between BMI and prognosis, specifically all-cause mortality and hospital admissions for worsening HF, in a cohort of Japanese chronic HF patients.
  • To determine if a specific BMI range is associated with optimal outcomes in this patient demographic.

Main Methods:

  • Analysis of data from the Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART) study, involving 972 Japanese chronic HF patients.
  • Patients were stratified into five BMI categories: <18.5, 18.5–22.9, 23.0–24.9 (reference), 25.0–29.9, and ≥30.0.
  • Cox proportional hazards models were employed to assess the relationship between BMI categories and clinical endpoints over a mean follow-up of 3.4 years.

Main Results:

  • Multivariate analysis revealed a U-shaped association between BMI and all-cause mortality compared to the reference group (BMI 23.0–24.9).
  • Hazard ratios (HR) for all-cause death were elevated in the lowest BMI group (BMI <18.5, HR=1.70) and the highest BMI group (BMI ≥30.0, HR=2.75).
  • Significant U-shaped associations were also observed for cardiac-cause death and hospital admissions due to worsening HF.

Conclusions:

  • Both underweight and obesity are associated with increased adverse outcomes in Japanese patients with chronic heart failure.
  • Extreme BMI values, both low and high, do not confer a survival benefit and may negatively impact prognosis in this population.
Abstract

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