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Updated: Jun 7, 2026
05:18
Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
Published on: March 14, 2016
Immunotherapy throughout the decades: from Noon to now
Ira Finegold1, Robert J Dockhorn, Daniel Ein
1Department of Allergy, St. Luke's-Roosevelt Hospital, New York, New York 10022, USA. drfinegold@AOL.com
Summary
Subcutaneous allergen immunotherapy has significantly improved allergic rhinitis and asthma management over decades. While efficacy was established early, research continues to uncover mechanisms and refine treatments for better patient outcomes.
Area of Science:
- Allergy and Immunology
- Immunotherapy Research
Background:
- Subcutaneous allergen immunotherapy (SCIT) has a long history of clinical application.
- Early SCIT demonstrated efficacy in allergic rhinitis and asthma, predating mechanistic understanding.
Purpose of the Study:
- To chronicle key advancements in subcutaneous allergen immunotherapy development.
- To examine the evolution of SCIT over 20-year intervals.
Main Methods:
- A comprehensive literature review was conducted.
- Relevant articles and textbooks detailing SCIT milestones were selected.
Main Results:
- SCIT has successfully treated millions with hay fever, asthma, and insect venom hypersensitivity.
- Significant improvements in administration methods, materials, and safety have been achieved.
- Mechanisms of SCIT efficacy are increasingly understood, though not fully elucidated.
Conclusions:
- Despite substantial progress, ongoing research is necessary.
- Further improvements in SCIT are anticipated to benefit more patients.
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