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Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Published on: May 10, 2020

Hepatic progenitor cells: an update.

Tania Roskams¹, Aezam Katoonizadeh, Mina Komuta

¹Liver Research Unit, Department of Morphology and Molecular Pathology, University of Leuven, Minderbroederstraat 12, Leuven, Belgium. tania.roskams@uz.kuleuven.ac.be

Clinics in Liver Disease

|November 9, 2010

Summary

Liver progenitor cells activate differently in acute vs. chronic liver diseases. Manipulating Wnt and Notch pathways offers therapeutic potential for liver regeneration, potentially reducing the need for transplants.

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Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

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Published on: February 18, 2017

Area of Science:

Hepatology
Cell Biology
Regenerative Medicine

Background:

Liver progenitor cells (LPCs) activate in most human liver diseases.
LPC dynamics and subpopulations vary between acute, chronic hepatocytic, and biliary diseases.

Purpose of the Study:

To investigate the role of Wnt and Notch signaling pathways in LPC activation and differentiation.
To explore therapeutic strategies for modulating LPCs to promote liver regeneration.

Main Methods:

Analysis of LPC dynamics in different liver disease models.
Investigating the effects of Wnt and Notch pathway modulation on LPC differentiation.

Main Results:

Wnt and Notch signaling pathways are crucial for LPC activation and differentiation.
Hepatocytic differentiation is induced by Notch inhibition (Numb activation).
Cholangiocytic differentiation is promoted by Notch activation.

Conclusions:

Targeting Wnt and Notch pathways offers a promising therapeutic strategy for liver diseases.
Modulating LPCs can support the body's regenerative response.
This approach may reduce the need for liver transplantation in some patients.