Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Narrative Review of the Metabolic Assessment of Patients on Methadone: An Alternative to Pharmacokinetically Blind Prescribing.

Journal of addiction medicine·2026
Same author

Treatment retention and reductions in blood alcohol concentration (BAC) during the first 90 days of a telehealth program for alcohol use disorder.

The American journal of drug and alcohol abuse·2023
Same author

The Use of the Methadone/Metabolite Ratio (MMR) to Identify an Individual Metabolic Phenotype and Assess Risks of Poor Response and Adverse Effects: Towards Scientific Methadone Dosing.

Journal of addiction medicine·2020
Same author

Effects of the Psychedelic Amphetamine MDA (3,4-Methylenedioxyamphetamine) in Healthy Volunteers.

Journal of psychoactive drugs·2019
Same author

Information Technologies: An Augmentation to Post-Traumatic Stress Disorder Treatment Among Trauma Survivors.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association·2018
Same author

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline.

Translational psychiatry·2018
Same journal

Effect of Australian telepsychiatry services on attention-deficit hyperactivity disorder prescriptions.

Psychiatry research·2026
Same journal

Cognitive correlates of Antisaccade Task performance in bipolar disorder.

Psychiatry research·2026
Same journal

National estimates of exposure to potentially traumatic events among individuals with obsessive-compulsive disorder: Findings from The National OCD Survey.

Psychiatry research·2026
Same journal

Digitally delivered cognitive bias modification for interpretation targeting hostile interpretation bias in compulsory drug rehabilitation: A feasibility randomized trial.

Psychiatry research·2026
Same journal

Association of TyG-RFM with depressive symptoms: a nationally representative study enhanced by interpretable machine learning.

Psychiatry research·2026
Same journal

Cross-national patterns of probable complex PTSD in post-communist Europe: A network analysis of five countries.

Psychiatry research·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Psychiatric comorbidity in methamphetamine dependence.

Ruth Salo1, Keith Flower, Anousheh Kielstein

  • 1Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA, USA.

Psychiatry Research
|November 9, 2010
PubMed
Summary
This summary is machine-generated.

Methamphetamine (MA) dependence frequently co-occurs with psychiatric disorders, including psychosis, mood, and anxiety conditions. These comorbidities, particularly MA-induced psychosis, are more prevalent in males and significantly impact mental health services.

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Related Experiment Videos

Last Updated: Jun 6, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Area of Science:

  • Psychiatry
  • Addiction Medicine
  • Neuroscience

Background:

  • Methamphetamine (MA) dependence is a significant public health concern.
  • Understanding psychiatric comorbidities in MA dependence is crucial for effective treatment and resource allocation.
  • Previous research may have limitations regarding sample diversity or diagnostic scope.

Purpose of the Study:

  • To determine the prevalence of psychiatric comorbidities in a large, diverse sample of MA-dependent individuals.
  • To investigate gender differences in the prevalence of these comorbidities.
  • To characterize specific diagnoses, including substance-induced disorders.

Main Methods:

  • A large sample of 189 MA-dependent subjects was recruited.
  • Validated Structured Clinical Interviews for DSM-IV (SCIDs) were administered.
  • Lifetime prevalence of psychiatric diagnoses was assessed, with attention to substance-induced conditions.

Main Results:

  • High rates of psychiatric comorbidity were observed, including psychotic disorders (28.6%), mood disorders (32.3% non-substance-induced), and anxiety disorders (26.5%).
  • Substantial proportions of disorders were substance-induced, particularly MA-induced psychosis (delusions and hallucinations) and anxiety.
  • Male subjects reported higher rates of MA-induced delusions compared to females.

Conclusions:

  • Methamphetamine dependence is strongly associated with a high prevalence of diverse psychiatric comorbidities.
  • Substance-induced psychiatric conditions, especially psychosis, are common in MA users.
  • Gender appears to influence the presentation of certain MA-induced psychiatric symptoms, highlighting the need for tailored interventions.