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Updated: Aug 19, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
The diagnosis of herniated intervertebral disks with MR imaging: a comparison of gradient-refocused-echo and
S Murayama1, Y Numaguchi, A E Robinson
1Department of Radiology, Tulane University Medical Center, New Orleans, LA 70112.
Abstract:
Axial MR images of 65 lumbar disks with herniated nucleus pulposus imaged by gradient-refocused-echo (GRE) and spin-echo (SE) MR pulse sequences of 200-400/15 with a flip angle of 15-30 degrees was selected as optimal because of its high signal-to-noise ratio and good contrast between CSF, nucleus pulposus, and bone. The GRE technique was confirmed to be more sensitive in detecting prolapsed disks than the SE technique, but was less sensitive in demonstrating extruded disks. The combination of axial GRE and SE resulted in high detectability of herniated nucleus pulposus on axial MR images. Our results suggest that the GRE technique is an important adjunct to SE imaging in studying herniated nucleus pulposus.
Insights
Gradient-refocused-echo (GRE) and spin-echo (SE) magnetic resonance imaging (MRI) techniques effectively detect herniated nucleus pulposus. Combining GRE and SE MRI enhances the detection of prolapsed and extruded lumbar disks.
Area of Science:
- Radiology
- Medical Imaging
- Orthopedics
Background:
- Lumbar disk herniation is a common condition affecting the spine.
- Accurate imaging is crucial for diagnosing and managing herniated nucleus pulposus.
- Magnetic resonance imaging (MRI) is a primary modality for visualizing spinal structures.
Purpose of the Study:
- To evaluate the effectiveness of gradient-refocused-echo (GRE) and spin-echo (SE) MRI sequences for imaging lumbar disk herniation.
- To compare the sensitivity of GRE and SE techniques in detecting different types of herniated nucleus pulposus.
- To determine the optimal MRI approach for visualizing herniated lumbar disks.
Main Methods:
- Axial MR images of 65 lumbar disks with herniated nucleus pulposus were acquired.
- Gradient-refocused-echo (GRE) and spin-echo (SE) pulse sequences were utilized.
- Image analysis focused on signal-to-noise ratio and contrast between cerebrospinal fluid (CSF), nucleus pulposus, and bone.
Main Results:
- The GRE technique demonstrated higher sensitivity in detecting prolapsed disks compared to SE.
- The SE technique was more sensitive in visualizing extruded disks.
- A combination of axial GRE and SE sequences resulted in high overall detectability of herniated nucleus pulposus.
Conclusions:
- The GRE technique is a valuable adjunct to SE imaging for studying herniated nucleus pulposus.
- Combining GRE and SE MRI sequences improves the comprehensive evaluation of lumbar disk herniation.
- Optimized MRI protocols enhance diagnostic accuracy for spinal conditions.
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