The role of dopamine in the dorsomedial striatum in place and response learning

The posterior subregion of the dorsomedial striatum (pDMS) has been implicated in spatial learning. Here we investigated the role of dopamine (DA) signals in the pDMS in place and response learning using a T-maze task. Rats subjected to a DA depletion of the pDMS and sham controls were trained for 7 days to retrieve food from the west arm of the maze starting from the south, that is to make a left turn at the choice point. On day 8, a probe test was given in which the starting arm was inserted as the north arm. On days 9-16 animals received further training, and on day 17, a second probe test was performed. We examined whether animals responded on probe tests according to a response strategy (left turn at choice point) or to a place strategy (right turn at choice point). Our results revealed that, unlike sham controls, rats with a pDMS DA depletion preferentially used a response rather than a place strategy already on the first probe test. These findings provide further support for a role of the pDMS in spatially guided behavior and indicate that DA signals in the pDMS are critical for the use of a place strategy.