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Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
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Pain in osteoarthritis.

P René van Weeren1, Janny C de Grauw

  • 1Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, NL-3584 CM, Utrecht, The Netherlands. R.vanWeeren@uu.nl

The Veterinary Clinics of North America. Equine Practice
|November 9, 2010
PubMed
Summary

This review covers osteoarthritis (OA) pain, detailing joint biology, disease processes, and pain origins. It emphasizes pharmacologic management, including systemic and intra-articular treatments for joint pain relief.

Area of Science:

  • Rheumatology and Orthopedics
  • Biomedical Sciences

Background:

  • Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage breakdown and inflammation.
  • Understanding the pathophysiology of OA is crucial for effective pain management.

Purpose of the Study:

  • To provide a comprehensive overview of osteoarthritis (OA) pain.
  • To discuss the biological basis of OA and its associated pain mechanisms.
  • To review current pharmacologic and non-pharmacologic management strategies for OA pain.

Main Methods:

  • Literature review focusing on the biology of articular cartilage and OA.
  • Discussion of pain origins in OA.
  • Analysis of pharmacologic (systemic and intra-articular) treatment modalities.
  • Brief mention of non-medical pain modulation techniques.

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Main Results:

  • OA pain arises from complex interactions involving joint structures and disease processes.
  • Pharmacologic interventions, both systemic and local, are key to managing OA joint pain.
  • While non-medical approaches exist, the focus remains on therapeutic drug strategies.

Conclusions:

  • Effective management of osteoarthritis (OA) pain requires a thorough understanding of its biological underpinnings.
  • Pharmacologic therapies represent the cornerstone of OA pain management, with systemic and intra-articular options available.
  • A multimodal approach, considering various treatment modalities, is essential for optimizing patient outcomes in OA.