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Updated: Jun 6, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
The expression of bipolar spectrum psychopathology in daily life
Thomas R Kwapil1, Neus Barrantes-Vidal, Molly S Armistead
1University of North Carolina at Greensboro, United States. t_kwapil@uncg.edu
Background:
Bipolar psychopathology has traditionally been defined by categorical diagnoses. However, these disorders may simply reflect the extremes of a broader spectrum of clinical and subclinical bipolar psychopathology.
Method:
The present study examined the validity of the Hypomanic Personality Scale (HPS) as a measure of bipolar spectrum psychopathology in 305 young adults using experience sampling methodology. The participants completed the HPS and were signaled randomly eight times daily for seven days to complete brief questionnaires on their current experiences.
Results:
High HPS scores were associated with elevated energetic-enthusiasm, irritability, dysphoria, flight of ideas, mild grandiose beliefs, and risky behavior, as well as increased variability in affect in daily life. High HPS scores were also associated with greater reactivity in negative affect and behavior in response to viewing themselves as unsuccessful in their activities.
Limitations:
It is not clear to what extent the participants had diagnosable bipolar disorders.
Conclusions:
The findings support a broader spectrum of bipolar psychopathology and the validity of the HPS as a measure of this construct.
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