Biological mechanisms of implant osseointegration

Osseointegration is the development of a stable connection between the recipient bone and the implant surface. This process is a function of the time it takes for the implant to become fixed in bone tissue. The essence of osseointegration is the achievement of permanent stability of the implant, which ensures the proper course of the healing process, and "acceptance" of the implant by the living bone tissue, which leads to the initiation of osteogenesis and formation of young bone on the surface of the bone graft. Bone reconstruction within the implant depends on the specific factors related both to the implant material properties and to the status of the patient's skeletal system. High biocompatibility of the implant material ensures the maintenance of permanent and stable bone-implant contact and successful normal osseointegration. This work presents the cellular and extracellular mechanisms and factors influencing the process of osseointegration.