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Related Experiment Video

Updated: Jun 6, 2026

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
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Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

Real-time free cortisol quantification among critically ill children.

Jerry J Zimmerman1, Amy Donaldson, Ruth M Barker

  • 1Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA. jerry.zimmerman@seattlechildrens.org

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|November 9, 2010
PubMed
Summary

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This summary is machine-generated.

Measuring free cortisol in critically ill children using centrifugal ultrafiltration is fast and accurate. This method can potentially guide treatment decisions for cortisol replacement therapy in pediatric intensive care units.

Area of Science:

  • Endocrinology
  • Pediatric Critical Care
  • Clinical Chemistry

Background:

  • Assessing adrenal function in critical illness often requires measuring free cortisol, but traditional methods are time-consuming.
  • Critical illness-related cortisol insufficiency (CIRCI) diagnosis may benefit from rapid free cortisol measurements.
  • Current gold-standard methods for free cortisol determination are logistically challenging in intensive care settings.

Purpose of the Study:

  • To evaluate centrifugal ultrafiltration as a rapid method for determining free cortisol concentrations in critically ill children.
  • To compare the accuracy of free cortisol measurements obtained by centrifugal ultrafiltration with equilibrium dialysis, the gold standard.
  • To investigate the correlation between free cortisol levels and illness severity in pediatric patients.

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Last Updated: Jun 6, 2026

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
08:25

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Published on: December 18, 2013

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
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Main Methods:

  • A prospective, multi-institutional, observational cohort study was conducted across seven pediatric intensive care units.
  • One hundred sixty-five critically ill children were enrolled.
  • Blood samples were analyzed for free cortisol using centrifugal ultrafiltration and equilibrium dialysis, with quantification by chemiluminescence immunoassay.

Main Results:

  • Centrifugal ultrafiltration provided free cortisol results in approximately 2 hours, compared to 24 hours for equilibrium dialysis.
  • A strong correlation (R2 = 0.97) was observed between free cortisol measurements from both methods.
  • Many children had free cortisol levels below suggested thresholds for CIRCI, yet lacked clinical signs of insufficiency, and illness severity showed a moderate correlation with free cortisol levels.

Conclusions:

  • Centrifugal ultrafiltration is a rapid and highly correlated method for measuring free cortisol compared to equilibrium dialysis.
  • A significant proportion of critically ill children have low free cortisol levels without clinical evidence of CIRCI.
  • Real-time free cortisol quantification using centrifugal ultrafiltration is feasible and may aid clinical decision-making for cortisol replacement therapy in pediatric intensive care units.