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Updated: Jun 6, 2026
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Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
Published on: January 17, 2025
Three cases of resected pleomorphic carcinoma
Ryutaro Kikuchi1, Noritaka Isowa, Hirokazu Tokuyasu
1Divisions of Thoracic Surgery, Respiratory Medicine, and Pathology, Matsue Red Cross Hospital, Shimane, Japan.
Summary
This study reports three cases of resected pleomorphic carcinoma (PC), a rare lung cancer. Outcomes varied, highlighting the need for more case reports to determine optimal management strategies for this uncommon malignancy.
Area of Science:
- Oncology
- Thoracic Surgery
- Pathology
Background:
- Pleomorphic carcinoma (PC) is an uncommon and aggressive subtype of non-small cell lung cancer.
- Resection is a primary treatment modality, but outcomes can be variable.
- Limited case series exist for PC, necessitating further reporting.
Purpose of the Study:
- To present three surgically resected cases of lung pleomorphic carcinoma.
- To describe the clinical presentation, treatment, and outcomes of these patients.
- To emphasize the need for additional case reports to guide management.
Main Methods:
- Retrospective review of three patients with pathologically confirmed lung PC.
- Surgical resection (lobectomy, segmentectomy) was performed for all cases.
- Adjuvant therapies including chemotherapy and radiotherapy were administered in select cases.
Main Results:
- Case 1: Stage IB (pT2N0M0) patient survived 56 months post-lobectomy with adjuvant chemotherapy.
- Case 2: Stage IIIA (pT2N2M0) patient died of infection during adjuvant chemotherapy post-lobectomy.
- Case 3: Stage IIB (pT3N0M0) patient died 9 months post-segmentectomy despite adjuvant radiotherapy.
Conclusions:
- Outcomes for resected lung pleomorphic carcinoma are highly variable.
- Adjuvant therapies may not prevent adverse outcomes in all cases.
- Further case accumulation and reporting are crucial for establishing optimal treatment guidelines for PC.
