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Updated: Jun 6, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Rab7b and receptors trafficking
Cecilia Bucci1, Oddmund Bakke, Cinzia Progida
1Department of Biological and Environmental Sciences and Technologies (DiSTeBA); University of Salento; Lecce, Italy.
Abstract:
Rab proteins are key-regulators of intracellular membrane trafficking. Rab7b is a recently identified Rab protein that may downregulate TLR4 and TLR9-mediated inflammatory responses. Rab7b, believed to have similar function as Rab7, controls however vesicular trafficking from endosomes to the TGN. It is localized to late endosomes/lysosomes as well as the TGN. Rab7b interferes with enzymes delivery to lysosomes and with the retrograde Shiga toxin transport to the Golgi. Furthermore, Rab7b depletion alters CI-MPR and TGN46 trafficking. In conclusion, Rab7b, by regulating the transport from late endosomes to the TGN, is fundamental for trafficking of several receptors, opening for a revised scenario for its influence on signaling of Toll-like Receptors (TLRs) and other receptors.
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