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Related Experiment Video

Updated: Jun 6, 2026

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration
08:43

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

Published on: February 1, 2022

Particle sorting using a porous membrane in a microfluidic device.

Huibin Wei1, Bor-han Chueh, Huiling Wu

  • 1The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Lab on a Chip
|November 9, 2010
PubMed
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This study presents a novel porous membrane filter for particle sorting. The microfluidic device effectively separates particles and blood components with high efficiency and no clogging.

Area of Science:

  • Microfluidics
  • Materials Science
  • Biotechnology

Background:

  • Porous membranes are crucial for separation technologies.
  • Existing methods face challenges with pore size control and clogging.
  • Microfluidic devices offer precise control over separation processes.

Purpose of the Study:

  • To develop a novel porous membrane filter with tunable pore sizes.
  • To demonstrate its application in efficient particle and blood component separation.
  • To address the issue of irreversible clogging in filtration systems.

Main Methods:

  • Fabrication of a monolithic 3D poly(dimethylsiloxane) microfluidic structure using a perforated membrane mold.
  • Creation of filters with pore sizes from 6.4 to 16.6 µm, and smaller openings (2.5 to 3.3 µm) by overlapping filters.

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Last Updated: Jun 6, 2026

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  • Implementation of a cross-flow system to prevent clogging during filtration.

    • Main Results:

    • Achieved precise control over pore sizes within the microfluidic device.
    • Demonstrated clog-free operation using the integrated cross-flow system.
    • Separated polystyrene beads with >99.9% efficiency.
    • Successfully separated whole blood into white blood cells, red blood cells, and platelets.

    Conclusions:

    • The developed porous membrane filter offers a robust solution for particle and cell separation.
    • The microfluidic design with cross-flow effectively prevents clogging, enhancing device longevity.
    • This technology shows significant potential for applications in diagnostics and cell analysis.