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Injection molded nanofluidic chips: fabrication method and functional tests using single-molecule DNA experiments.

Pawel Utko1, Fredrik Persson, Anders Kristensen

  • 1DTU Nanotech, Department of Micro and Nanotechnology, Technical University of Denmark, DK-2800, Kongens Lyngby, Denmark. pawel@fys.ku.dk

Lab on a Chip
|November 9, 2010
PubMed
Summary

Injection molding simplifies nanofluidic chip fabrication using thermoplastic polymers. This cost-effective, all-polymer platform enables lab-on-a-chip applications, demonstrated by DNA stretching in nanochannels.

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Area of Science:

  • Materials Science
  • Microfluidics
  • Nanotechnology

Background:

  • Fabricating well-defined nanofluidic systems is complex and costly.
  • Current methods often require specialized equipment and multiple processing steps.

Purpose of the Study:

  • To develop a simplified, cost-effective fabrication method for nanofluidic systems.
  • To demonstrate the utility of injection molding for creating polymer-based lab-on-a-chip devices.

Main Methods:

  • Utilizing injection molding for thermoplastic polymers to create chips with nanochannel arrays, microchannels, and interconnects in a single step.
  • Employing plasma-enhanced thermal bonding to seal the open channel structures with a polymer film.

Main Results:

  • Successfully fabricated all-polymer nanofluidic chips via injection molding and thermal bonding.
  • Demonstrated the platform's capability through DNA stretching experiments on individual double-stranded DNA molecules within the nanochannels.
  • Achieved results consistent with those from expensive silica nanochannels.

Conclusions:

  • Injection molding offers a fast, inexpensive, and industry-compatible method for producing single-use nanofluidic lab-on-a-chip platforms.
  • The developed method simplifies the fabrication of complex nanofluidic devices.
  • This approach is suitable for various nanofluidic applications, including biological molecule analysis.