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Updated: Jun 6, 2026
05:09
Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
Published on: February 8, 2022
Long-duration (>4 weeks) continuous renal replacement therapy in critical illness
1Columbia University College of Physicians and Surgeons, Children's Hospital of New York-Presbyterian, New York, NY 10032, USA. jsb106@columbia.edu
The International Journal of Artificial Organs
|November 9, 2010
Summary
Long-duration continuous renal replacement therapy (CRRT) in critically ill children showed similar survival rates compared to shorter durations. This study clarifies outcomes for prolonged CRRT use in pediatric intensive care.
Area of Science:
- Pediatric Critical Care Medicine
- Nephrology
- Renal Replacement Therapy
Background:
- Continuous renal replacement therapy (CRRT) is used in critically ill children.
- Concerns exist regarding outcomes with prolonged CRRT (>4 weeks).
- The practice of long-duration CRRT in pediatrics is not well-described.
Observation:
- A retrospective chart review identified 39 pediatric patients treated with CRRT.
- Most patients had multiorgan dysfunction syndrome and required vasopressors.
- Median age was 6 years, with a significant proportion being infants.
Findings:
- Overall survival was 38%.
- Patients receiving long-duration CRRT (group 1) and shorter-duration CRRT (group 2) had similar demographics and baseline illness severity.
- Survival rates were comparable between the long-duration and shorter-duration CRRT groups (p=1).
Implications:
- Long-duration CRRT in critically ill children does not appear to negatively impact survival rates.
- Findings support the use of CRRT for extended periods when clinically indicated in pediatric patients.
- Further research may explore specific indications and optimal management strategies for prolonged CRRT.
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