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Related Experiment Videos

Concomitant continuous infusion chemotherapy and radiation.

M Rotman1, H Aziz

  • 1Department of Radiation Oncology, State University of New York, Brooklyn 11203-2098.

Cancer
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

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Continuous infusion chemotherapy given concomitantly with irradiation (CCIC and RT) significantly increases tumor cell killing and survival rates for various epithelial cancers. This combined approach offers improved locoregional control and organ preservation, demonstrating efficacy in advanced and lower-staged cancers.

Area of Science:

  • Radiation Oncology
  • Medical Oncology
  • Cancer Research

Background:

  • Attempts to enhance radiation therapy's cytotoxic effects led to exploring various radiosensitizing techniques.
  • Nitroimidazole compounds, initially promising for radiosensitization, have not met clinical expectations.
  • Pharmacokinetic and cytokinetic studies suggest synergistic effects between continuous infusion chemotherapy and irradiation.

Purpose of the Study:

  • To evaluate the efficacy of concomitant continuous infusion chemotherapy and irradiation (CCIC and RT) in improving cancer treatment outcomes.
  • To assess the impact of CCIC and RT on locoregional control, survival rates, and organ preservation in various epithelial cancers.

Main Methods:

  • CCIC and RT regimens were investigated, often involving agents like 5-fluorouracil (5-FU), mitomycin C, and cisplatin.

Related Experiment Videos

  • Treatment protocols were applied to various epithelial cancers, including anal, bladder, cervical, head and neck, and paranasal sinus carcinomas.
  • Outcomes such as local control rates, 5-year survival rates, and sphincter preservation were analyzed.

    • Main Results:

    • CCIC and RT demonstrated significantly higher local control rates and improved survival compared to historical controls or radiation alone for multiple cancer types.
    • For anal carcinoma, CCIC and RT achieved 90%-100% local control and 80%-86% 5-year survival with 90% sphincter preservation.
    • Transitional cell carcinoma of the bladder showed 71%-86% local control and 62% 5-year survival with 5-FU CCIC and RT.
    • Stage III/IV cervical carcinoma treated with 5-FU CCIC, cisplatin, and RT yielded 74% locoregional control.
    • Advanced head and neck cancers treated with cisplatin CCIC and hyperfractionated RT showed an 87% complete response rate.

    Conclusions:

    • CCIC and RT represent a synergistic approach that significantly enhances tumor cell killing and improves treatment outcomes for epithelial cancers.
    • This combined modality offers superior locoregional control and survival benefits, with notable success in organ-sparing applications.
    • CCIC and RT are effective in treating both advanced and lower-staged epithelial carcinomas, including challenging cases with bone destruction.