Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of pH-Responsive Ionisable Lipid Nanoparticles as Cisplatin Delivery Vehicles for Treating Cisplatin-Resistant Ovarian Cancer.

Pharmaceutics·2026
Same author

Aptamer-Loaded Cubosome Lipid Nanoparticles for the Treatment of Tuberculosis.

ACS applied materials & interfaces·2026
Same author

Review of carbon dioxide removal and recycling in space.

NPJ microgravity·2026
Same author

Spin-Dependent Photoluminescence in Carbon-Based Quantum Dots.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Preventing resistance development in infections by OXA β-lactamase-producing Pseudomonas aeruginosa: correlating clinical outcomes with hollow-fibre model input.

The Journal of antimicrobial chemotherapy·2025
Same author

Structure-Function Correlation of Clinically Inspired Lipid Nanoparticles for Lung and Spleen Targeted mRNA Delivery.

Advanced healthcare materials·2025
Same journal

Laser-Assisted Electrochemical Deposition of Bilateral Au Coatings on Ni Foils: Mechanism and Experimental Study.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Mechanistic Insights into Pulmonary Surfactant Inactivation.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

MPN-GE Bilayer Interphase Construction: Green Modification Derived from Biomass and Synergistic Enhancement of CFRP.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Magnetically Retrievable Core@Shell Nanocomposites for Rare Earth Element Adsorption: Experimental and Machine Learning Insights.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Microstreaming of a Pneumatically Controlled Bubble under Hydrostatic Pressure and Crossflow.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Tuning Pore Sizes of Core-Shell Dendritic Mesoporous Silica Nanoparticles for Efficient Loading of Functional Materials.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Nanostructured nonionic thymidine nucleolipid self-assembly materials.

Xavier Mulet1, Thomas Kaasgaard, Charlotte E Conn

  • 1CSIRO Materials Science and Engineering, Bag 10, Clayton South MDC, VIC 3169, Australia.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 10, 2010
PubMed
Summary
This summary is machine-generated.

Synthesized nucleoside lipids show potential for DNA-like interactions. Single-chain variants form liquid-crystalline phases, while dual-chain lipids do not, impacting their binding capabilities.

More Related Videos

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Related Experiment Videos

Last Updated: Jun 6, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Area of Science:

  • Lipid chemistry
  • Supramolecular chemistry
  • Materials science

Background:

  • Nucleoside lipids are amphiphilic molecules with potential applications in drug delivery and biomaterials.
  • Understanding their self-assembly and phase behavior is crucial for designing functional systems.

Purpose of the Study:

  • To synthesize and characterize novel nucleoside lipids with varying chain structures.
  • To investigate the physical properties and aqueous phase behavior of these nucleolipids.
  • To evaluate their potential for DNA-type binding and recognition.

Main Methods:

  • Synthesis of 3'-oleoylthymidine, 3',5'-dioleoylthymidine, and 3'-phytanoylthymidine.
  • Differential scanning calorimetry and X-ray diffraction for neat lipid characterization.
  • Polarizing optical microscopy, small-angle X-ray scattering, and cryo-transmission electron microscopy for phase behavior studies.
  • Langmuir trough measurements for DNA-type binding evaluation.

Main Results:

  • Neat oleoyl-based nucleoside lipids formed lamellar crystalline phases, while the phytanoyl derivative formed a fluid isotropic phase.
  • Single-chain nucleolipids (phytanoyl and oleoyl) adopted liquid-crystalline lamellar phases in excess water at physiological temperatures.
  • The dual-chain 3',5'-dioleoylthymidine derivative did not exhibit swelling or lyotropic liquid-crystalline phase behavior.
  • Single-chain nucleolipids showed available nucleoside bases for hydrogen bonding in monolayer studies, unlike the dual-chain amphiphile.

Conclusions:

  • The structure of the lipid chain significantly influences the self-assembly and phase behavior of nucleoside lipids.
  • Single-chain nucleoside lipids can form ordered liquid-crystalline phases and exhibit DNA-type binding potential.
  • Dual-chain nucleoside lipids display distinct properties, lacking swelling and lyotropic behavior, and altered binding characteristics.